The largest ever study of psilocybin – the psychoactive ingredient in magic mushrooms – has found the compound safe for treating depression.
Volunteers who received doses of the psychedelic compound experienced no serious adverse effects in phase one clinical trials at Kings College London (KCL).
Psilocybin has been tipped as a potentially groundbreaking treatment for mental health disorders that could replace antidepressants, with some research suggesting it could also aid those dealing with addiction.
“The results of the study are clinically reassuring and support further development of psilocybin as a treatment for patients with mental health problems that haven’t improved with conventional therapy, such as treatment resistant depression,” said KCL’s Dr James Rucker, the study’s lead investigator.
Most of the minor adverse events recorded were of the expected psychedelic nature, researchers found, with changes to sensory perception and mood, but no negative effects on cognitive and emotional functioning.
1/20 Jackdaws can identify ‘dangerous’ humans
Jackdaws can identify “dangerous” humans from listening to each other’s warning calls, scientists say. The highly social birds will also remember that person if they come near their nests again, according to researchers from the University of Exeter. In the study, a person unknown to the wild jackdaws approached their nest. At the same time scientists played a recording of a warning call (threatening) or “contact calls” (non-threatening). The next time jackdaws saw this same person, the birds that had previously heard the warning call were defensive and returned to their nests more than twice as quickly on average.
Getty
2/20 Turtle embryos influence sex by shaking
The sex of the turtle is determined by the temperatures at which they are incubated. Warm temperatures favour females.
But by wiggling around the egg, embryos can find the “Goldilocks Zone” which means they are able to shield themselves against extreme thermal conditions and produce a balanced sex ratio, according to the new study published in Current Biology journal
Ye et al/Current Biology
3/20 Elephant poaching rates drop in Africa
African elephant poaching rates have dropped by 60 per cent in six years, an international study has found. It is thought the decline could be associated with the ivory trade ban introduced in China in 2017.
Reuters
4/20 Ancient four-legged whale discovered in Peru
Scientists have identified a four-legged creature with webbed feet to be an ancestor of the whale. Fossils unearthed in Peru have led scientists to conclude that the enormous creatures that traverse the planet’s oceans today are descended from small hoofed ancestors that lived in south Asia 50 million years ago
A. Gennari
5/20 Animal with transient anus discovered
A scientist has stumbled upon a creature with a “transient anus” that appears only when it is needed, before vanishing completely. Dr Sidney Tamm of the Marine Biological Laboratory could not initially find any trace of an anus on the species. However, as the animal gets full, a pore opens up to dispose of waste
Steven G Johnson
6/20 Giant bee spotted
Feared extinct, the Wallace’s Giant bee has been spotted for the first time in nearly 40 years. An international team of conservationists spotted the bee, that is four times the size of a typical honeybee, on an expedition to a group of Indonesian Islands
Clay Bolt
7/20 New mammal species found inside crocodile
Fossilised bones digested by crocodiles have revealed the existence of three new mammal species that roamed the Cayman Islands 300 years ago. The bones belonged to two large rodent species and a small shrew-like animal
New Mexico Museum of Natural History
8/20 Fabric that changes according to temperature created
Scientists at the University of Maryland have created a fabric that adapts to heat, expanding to allow more heat to escape the body when warm and compacting to retain more heat when cold
Faye Levine, University of Maryland
9/20 Baby mice tears could be used in pest control
A study from the University of Tokyo has found that the tears of baby mice cause female mice to be less interested in the sexual advances of males
Getty
10/20 Final warning to limit “climate catastrophe”
The Intergovernmental Panel on Climate Change has issued a report which projects the impact of a rise in global temperatures of 1.5 degrees Celsius and warns against a higher increase
Getty
11/20 Nobel prize for evolution chemists
The nobel prize for chemistry has been awarded to three chemists working with evolution. Frances Smith is being awarded the prize for her work on directing the evolution of enzymes, while Gregory Winter and George Smith take the prize for their work on phage display of peptides and antibodies
Getty/AFP
12/20 Nobel prize for laser physicists
The nobel prize for physics has been awarded to three physicists working with lasers. Arthur Ashkin (L) was awarded for his “optical tweezers” which use lasers to grab particles, atoms, viruses and other living cells. Donna Strickland and Gérard Mourou were jointly awarded the prize for developing chirped-pulse amplification of lasers
Reuters/AP
13/20 Discovery of a new species of dinosaur
The Ledumahadi Mafube roamed around 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, it was the largest land animal of its time, weighing 12 tons and standing at 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means “a giant thunderclap at dawn”
Viktor Radermacher / SWNS
14/20 Birth of a planet
Scientists have witnessed the birth of a planet for the first time ever. This spectacular image from the SPHERE instrument on ESO’s Very Large Telescope is the first clear image of a planet caught in the very act of formation around the dwarf star PDS 70. The planet stands clearly out, visible as a bright point to the right of the center of the image, which is blacked out by the coronagraph mask used to block the blinding light of the central star.
ESO/A. Müller et al
15/20 New human organ discovered that was previously missed by scientists
Layers long thought to be dense, connective tissue are actually a series of fluid-filled compartments researchers have termed the “interstitium”. These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins
Getty
16/20 Previously unknown society lived in Amazon rainforest before Europeans arrived, say archaeologists
Working in the Brazilian state of Mato Grosso, a team led by archaeologists at the University of Exeter unearthed hundreds of villages hidden in the depths of the rainforest. These excavations included evidence of fortifications and mysterious earthworks called geoglyphs
José Iriarte
17/20 One in 10 people have traces of cocaine or heroin on fingerprints, study finds
More than one in 10 people were found to have traces of class A drugs on their fingers by scientists developing a new fingerprint-based drug test.
Using sensitive analysis of the chemical composition of sweat, researchers were able to tell the difference between those who had been directly exposed to heroin and cocaine, and those who had encountered it indirectly.
Getty
18/20 Nasa releases stunning images of Jupiter’s great red spot
The storm bigger than the Earth, has been swhirling for 350 years. The image’s colours have been enhanced after it was sent back to Earth.
Pictures by: Tom Momary
19/20 A 3D reconstruction of an African grey parrot post euthanasia
Included in Wellcome Image Awards, this 3D image of an African grey parrot shows the highly intricate system of blood vessels.
Scott Birch. Wellcome Images
20/20 Baby Hawaiian bobtail squid
Another Wellcome Images Award winner, this time of baby Hawaiian bobtail squid. The black ink sac and light organ in the centre of the squid’s mantle cavity can be clearly seen.
Macroscopic Solutions. Wellcome Images
1/20 Jackdaws can identify ‘dangerous’ humans
Jackdaws can identify “dangerous” humans from listening to each other’s warning calls, scientists say. The highly social birds will also remember that person if they come near their nests again, according to researchers from the University of Exeter. In the study, a person unknown to the wild jackdaws approached their nest. At the same time scientists played a recording of a warning call (threatening) or “contact calls” (non-threatening). The next time jackdaws saw this same person, the birds that had previously heard the warning call were defensive and returned to their nests more than twice as quickly on average.
Getty
2/20 Turtle embryos influence sex by shaking
The sex of the turtle is determined by the temperatures at which they are incubated. Warm temperatures favour females.
But by wiggling around the egg, embryos can find the “Goldilocks Zone” which means they are able to shield themselves against extreme thermal conditions and produce a balanced sex ratio, according to the new study published in Current Biology journal
Ye et al/Current Biology
3/20 Elephant poaching rates drop in Africa
African elephant poaching rates have dropped by 60 per cent in six years, an international study has found. It is thought the decline could be associated with the ivory trade ban introduced in China in 2017.
Reuters
4/20 Ancient four-legged whale discovered in Peru
Scientists have identified a four-legged creature with webbed feet to be an ancestor of the whale. Fossils unearthed in Peru have led scientists to conclude that the enormous creatures that traverse the planet’s oceans today are descended from small hoofed ancestors that lived in south Asia 50 million years ago
A. Gennari
5/20 Animal with transient anus discovered
A scientist has stumbled upon a creature with a “transient anus” that appears only when it is needed, before vanishing completely. Dr Sidney Tamm of the Marine Biological Laboratory could not initially find any trace of an anus on the species. However, as the animal gets full, a pore opens up to dispose of waste
Steven G Johnson
6/20 Giant bee spotted
Feared extinct, the Wallace’s Giant bee has been spotted for the first time in nearly 40 years. An international team of conservationists spotted the bee, that is four times the size of a typical honeybee, on an expedition to a group of Indonesian Islands
Clay Bolt
7/20 New mammal species found inside crocodile
Fossilised bones digested by crocodiles have revealed the existence of three new mammal species that roamed the Cayman Islands 300 years ago. The bones belonged to two large rodent species and a small shrew-like animal
New Mexico Museum of Natural History
8/20 Fabric that changes according to temperature created
Scientists at the University of Maryland have created a fabric that adapts to heat, expanding to allow more heat to escape the body when warm and compacting to retain more heat when cold
Faye Levine, University of Maryland
9/20 Baby mice tears could be used in pest control
A study from the University of Tokyo has found that the tears of baby mice cause female mice to be less interested in the sexual advances of males
Getty
10/20 Final warning to limit “climate catastrophe”
The Intergovernmental Panel on Climate Change has issued a report which projects the impact of a rise in global temperatures of 1.5 degrees Celsius and warns against a higher increase
Getty
11/20 Nobel prize for evolution chemists
The nobel prize for chemistry has been awarded to three chemists working with evolution. Frances Smith is being awarded the prize for her work on directing the evolution of enzymes, while Gregory Winter and George Smith take the prize for their work on phage display of peptides and antibodies
Getty/AFP
12/20 Nobel prize for laser physicists
The nobel prize for physics has been awarded to three physicists working with lasers. Arthur Ashkin (L) was awarded for his “optical tweezers” which use lasers to grab particles, atoms, viruses and other living cells. Donna Strickland and Gérard Mourou were jointly awarded the prize for developing chirped-pulse amplification of lasers
Reuters/AP
13/20 Discovery of a new species of dinosaur
The Ledumahadi Mafube roamed around 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, it was the largest land animal of its time, weighing 12 tons and standing at 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means “a giant thunderclap at dawn”
Viktor Radermacher / SWNS
14/20 Birth of a planet
Scientists have witnessed the birth of a planet for the first time ever. This spectacular image from the SPHERE instrument on ESO’s Very Large Telescope is the first clear image of a planet caught in the very act of formation around the dwarf star PDS 70. The planet stands clearly out, visible as a bright point to the right of the center of the image, which is blacked out by the coronagraph mask used to block the blinding light of the central star.
ESO/A. Müller et al
15/20 New human organ discovered that was previously missed by scientists
Layers long thought to be dense, connective tissue are actually a series of fluid-filled compartments researchers have termed the “interstitium”. These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins
Getty
16/20 Previously unknown society lived in Amazon rainforest before Europeans arrived, say archaeologists
Working in the Brazilian state of Mato Grosso, a team led by archaeologists at the University of Exeter unearthed hundreds of villages hidden in the depths of the rainforest. These excavations included evidence of fortifications and mysterious earthworks called geoglyphs
José Iriarte
17/20 One in 10 people have traces of cocaine or heroin on fingerprints, study finds
More than one in 10 people were found to have traces of class A drugs on their fingers by scientists developing a new fingerprint-based drug test.
Using sensitive analysis of the chemical composition of sweat, researchers were able to tell the difference between those who had been directly exposed to heroin and cocaine, and those who had encountered it indirectly.
Getty
18/20 Nasa releases stunning images of Jupiter’s great red spot
The storm bigger than the Earth, has been swhirling for 350 years. The image’s colours have been enhanced after it was sent back to Earth.
Pictures by: Tom Momary
19/20 A 3D reconstruction of an African grey parrot post euthanasia
Included in Wellcome Image Awards, this 3D image of an African grey parrot shows the highly intricate system of blood vessels.
Scott Birch. Wellcome Images
20/20 Baby Hawaiian bobtail squid
Another Wellcome Images Award winner, this time of baby Hawaiian bobtail squid. The black ink sac and light organ in the centre of the squid’s mantle cavity can be clearly seen.
Macroscopic Solutions. Wellcome Images
The phase one trials – which sought to test the compound’s safety, not its therapeutic value – compared the effects of varying doses of the psilocybin-based drug COMP360 and placebos in 89 healthy volunteers.
There were 25 dosing sessions in total. In each session, six participants would receive either 10mg or 25mg doses or a placebo during a one-on-one session with a therapist lasting roughly six hours, with a follow-up period of 12 weeks.
Research by the company behind the trial, Compass Pathways, into using psilocybin as a treatment for depression has been fast-tracked in the US, receiving special “breakthrough therapy” status from the Food and Drug Administration.
It is currently running phase two studies across Europe and North America involving 216 patients who suffer with depression that hasn’t responded to treatment.
“This study is part of our overall clinical development programme in treatment-resistant depression,” Compass Pathways’ co-founder Dr Ekaterina Malievskaia said.
“We wanted to look at the safety and tolerability profile of our psilocybin, and to look at the feasibility of a model where up to six one-to-one sessions are held at the same time.
“We are focused on getting psilocybin therapy safely to as many patients who would benefit from it as possible [and] are grateful to the many pioneering research institutions whose work over the years has helped to demonstrate the potential of psilocybin in medicine.”
In June, The Independent reported that participants in the first trial comparing psilocybin to antidepressants at the world’s first psychedelic research centre, at Imperial College London, described a cathartic emotional “release” and “reconnection” during psilocybin therapy.
As the study’s lead Dr Robin Carhart-Harris pointed out, this is the polar opposite of antidepressants, which patients often complain leave their emotions “blunted”.