A new scientific study has been published showing that there is a link between two purine molecules, caffeine and urate, and Parkinson’s disease. Scientists have shown that increased caffeine consumption and increased levels of urate in the blood are effective against Parkinson’s.
Scientists from the Massachusetts Hospital and Harvard Medical School in the USA have made significant findings on the relationship between caffeine consumption and the level of urate in the blood and Parkinson’s disease. According to the data obtained by the researchers, high levels of caffeine and urate, which are purine molecules, provide protection against Parkinson’s disease.
Scientists who have researched various groups state that both caffeine and urate have protective properties. These properties are provided by the antioxidant activities of the adenosine receptor in the opposite direction. The anti-Parkinson disease effect of both molecules was also observed in animal models.
Study was done on 566 subjects:
Scientists conducted case-control studies on 369 idiopathic Parkinson patients and 197 healthy people within the scope of this research. On the first arrival of each subject, caffeine intakes in the last 12 months were determined and the results show that caffeine intakes are lower in those with Parkinson’s disease than healthy ones.
According to the findings, the prevalence of Parkinson’s in the fifth group that uses the most caffeine is 70% less than the one-fifth segment that uses the least caffeine. Similarly, an inverse proportion was found between the height of the urate level and Parkinson’s risk in both women and men. This is very important because the relationship between urate and Parkinson was previously thought to be gender-dependent.
However, researchers note that clinical trials that have recently increased the level of urate on Parkinson’s patients have failed. Although the new study establishes a relationship between low urate levels and Parkinson’s, increasing strategies for urate levels can be harmful and therefore not recommended. Likewise, it is stated that caffeine should be used primarily in long-term Parkinson experiments, therefore it is not recommended to increase the level of caffeine in Parkinson treatment at the moment.